Abstract
THE ESSENTIAL POINTS OF OUR RESULTS ARE AS FOLLOWS: The saprophytic Bacillus megatherium produced a definite pulmonary lesion which in gross appearance resembled the lesion of lobar pneumonia. The lesion was one of intense leucocytic exudation which, as in some other cases of experimental lobar pneumonia, did not invade the framework of the lung. But the exudate contained no fibrin. There were practically no bacilli, either in the heart's blood or in the lung. The growth of two colonies from one of the cases hardly changes the rule. The lesion did not progress after twenty-four hours; nor did it show a definite increase in extent or intensity with the increase in quantity of the injected cultures. The resolution of the exudate began practically at the end of twenty-four hours and was far advanced on the third day. Although there was considerable leucocytic infiltration there was no phagocytosis apparent twenty-four hours after inoculation. Taking all the facts into consideration one gains the impression that the lesion produced by the saprophytic Bacillus megatherium differs only quantitatively from that produced by an avirulent pneumococcus. The fact stands out prominently that a saprophytic bacterium is capable of producing a pneumonic lesion similar in gross appearance to that of mild lobar pneumonia. It is not improbable that other saprophytes may be capable of producing pneumonic lesions which, in specific instances, may resemble lobular pneumonia.
Highlights
In previous communications I on experimental pneumonia we showed that there are fundamental differences in the character of the pneumonic lesions produced by intrabronchial insufflation of different micro6rganisms
The lesion prod.uced by one group resembled that of lobar pneumonia, while the lesion produced by the other group resembled that of lobular pneumonia
Besides the known differences in their gross appearance, the two kinds of lesions were found to differ in two important points: (I) the exudate of experimental lobar pneumonia contained a great deal of fibrin, while that of lobular pneumonia had comparatively little; (2) in lobular pneumonia the leucocytic infiltration invaded the framework of the lungs, while in lobar pneumonia the framework remained free from infiltration
Summary
In previous communications I on experimental pneumonia we showed that there are fundamental differences in the character of the pneumonic lesions produced by intrabronchial insufflation of different micro6rganisms. (From the Departments of Pathology and of Physiology and Pharmacology of The Rockefeller Institute for Medical Research, New York.)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
