Production of ATP in leukocyte mitochondria from hyperthyroid patients before and after treatment with a beta-adrenergic blocker and antithyroid drugs.

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ABSTRACT The aerobic production of adenosine-triphosphate in leukocyte mitochondria from hyperthyroid patients was measured with an enzymatic method to detect firstly differences between normal and hyperthyroid subjects, and secondly differences between non-treated and treated hyperthyroid patients. The treatment consisted of either a β-adrenergic blocker or an antithyroid drug. Adenosine-triphosphate production is significantly decreased in hyperthyroidism and increases after treatment but does not reach the normal levels.