Abstract
Production and characterization of exopolysaccharide from marine Bacillus sp. MSHN2016 with studying its effect on isoniazid/ rifampicin-induced hepatic and renal toxicities in rats
Highlights
One of the reasons of 50% of the cases of acute liver failure is drug-induced hepatic toxicity which mimics all forms of liver disease (Kaplowitz, 2001)
EPSMSHN at both doses protected from the hepatic and renal toxicity induced by INH/RFP through its antioxidant and antifibrotic influence
It was known that EPSs are bioactive natural products used in different applications such as medical, the biochemical pharmacological application as a result of their specific biological activities (Ye et al, 2012; Selim et al, 2018)
Summary
One of the reasons of 50% of the cases of acute liver failure is drug-induced hepatic toxicity which mimics all forms of liver disease (Kaplowitz, 2001). The initial drugs utilized for tuberculosis help, are connected with hepatotoxicity (Kaplowitz, 2004). Those rate of hepatotoxicity needs to be been appeared to being substantially higher for creating nations such as India (8–30%) contrasted with that for propelled nations (Sharma, 2004). EPSs are high molecular weight polymers composed of homo- or heterocarbohydrates. They are produced by a different microorganism such as bacteria, fungi and yeasts, where they are secreted by these microorganisms to the external environment (Selim et al, 2018). It was known that EPSs are bioactive natural products used in different applications such as medical, the biochemical pharmacological application as a result of their specific biological activities (Ye et al, 2012; Selim et al, 2018)
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