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Abstract
The present invention is related to the synthetic preparation of 2-chloromethyl-3,5 Dimethyl-4-methoxy pyridine hydrochloride by using a greener chemistry approach and process optimization. The method consists of three steps. The first step is the methoxylation of 3,5- Dimethyl-4-nitropyridine-1-oxide by using sodium hydroxide and methanol to obtain 3,5 Dimethyl-4-methoxypyridine-1-oxide. The second step is methylation followed by hydroxylation of 3,5 Dimethyl-4-methoxypyridine-1-oxide by using dimethyl sulfate, Ammonium persulphate, hydrogen peroxide, and water to obtain 2-hydroxymethyl -3,5-dimethyl -4-methoxy pyridine. The third step is chlorination of 2- hydroxymethyl-3,5-dimethyl- 4-methoxy pyridine to obtain 2-chloromethyl-3,5-dimethyl-4-methoxy pyridine hydrochloride. The synthesis method of the 2-chloromethyl-3,5-dimethyl-4-methoxy pyridine hydrochloride was carried out without isolation of the first and second steps. It improves productivity and reduces the use of solvents. Mass spectra, Nuclear Magnetic Resonance, and C, H, N, and O elemental analysis characterized 2-chloromethyl-3,5- dimethyl-4-methoxy pyridine hydrochloride product.
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