Abstract
Potassium isopropoxide, involved in the cycle reaction of the intermediate dehydroester, is an important coupling agent in the production of drug pipemidic acid tablets. Current production problems of potassium isopropoxide by alkali method are the long period, the low productivity and the high energy consumption. To solve these problems, the reactive distillation production process of potassium isopropoxide was studied by simulation calculation and pilot experiment. The results show that the production process of potassium isopropanol is influenced by the separation efficiency and the reaction rate. The number of suitable theoretical plates for the column of azeotropic distillation is 14. The dissolution of solid potassium hydroxide is promoted and the reaction rate is increased, when a small amount of water is added to the raw material. It is found that the water content in the reflux organic phase can be reduced by lowering the liquid temperature in the condenser. It is also observed that suitable process conditions and the new type phase splitter can greatly reduced the production time of each batch of potassium isopropoxide.
Highlights
Pipemidic acid is yellowish or faint yellow crystalline powder, odourless and bitter in taste
Potassium isopropoxide is an important coupling agent in the production of drug pipemidic acid, and it is involved in the cycle reaction of the intermediate dehydroester
The phase splitter was set after the rectification column condenser in simulation calculation of azeotropic distillation, so the organic phase was completely refluxed and the aqueous phase flowed out of the system to be recycled
Summary
Pipemidic acid is yellowish or faint yellow crystalline powder, odourless and bitter in taste. It has a very good impact on acute or chronic pyelonephritis and bacterial intestinal infection caused by sensitive bacteria. Potassium isopropoxide is an important coupling agent in the production of drug pipemidic acid, and it is involved in the cycle reaction of the intermediate dehydroester. The only production facility of potassium isopropoxide was established by Shandong Xinhua Pharmaceutical Co., Ltd. in China in the early 1980s, which provided the raw material guarantee for the production of drug pipemidic acid. The original practical problems of long-term reactive distillation (72 h) and low production capacity have been exposed with the renewal of drug pipemidic acid production processes. It is urgent to carry out the optimization research and the design of the original process
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