Abstract
In humans, abnormal Mg2+ homeostasis is associated with many pathophysiological conditions. Despite Mg2+being the most abundant divalent cation present in the cell, the mechanism of Mg2+ transport and homeostasis are poorly understood. The Mg2+ channel MgtE is the primary magnesium transport system in ∼50% of bacteria, and is an ortholog of the mammalian SLC41A1 transporter, which has been implicated in Parkinson’s disease and head/neck cancer. The full-length MgtE from Thermus thermophilus is a homodimeric Mg2+ channel, which contains transmembrane and cytosolic domains.
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