Abstract
The magnesium channel MgtE is the primary magnesium transport system in ∼50% of bacteria, and its eukaryotic homologs are SLC41 family of solute carriers. The full-length MgtE from T. thermophilus is a homodimeric Mg2+ channel, which contains transmembrane and cytosolic domains. The cytoplasmic domain is divided into two sub-domains, namely the super-helical N-domain and cystathione-β-synthase (CBS) domain. The N-domain, in particular, is proposed to primarily function as a Mg2+ sensor. Here, we have monitored the folding and structural stability of the isolated cytoplasmic domain of MgtE (MgtETT-CD) in the presence of protein denaturing conditions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
