Abstract
Neurofilaments (NFs) are neuronal intermediate filaments that play important roles in axonal structure. NFs are composed of several subunit proteins including neurofilament light (NF-L), medium (NF-M), and heavy (NF-H), each with a “sidearm” intrinsically disordered region (IDR) that protrudes from the filament core to create a bottlebrush-like architecture. The length and charge of these sidearm IDRs vary widely between the different NF subunit proteins, and the relative abundance of different sidearm IDRs may govern inter-filament interactions and spacing via changes in the bottlebrush morphology.
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