Abstract
In the pituitary and areas of the brain the cellular and subcellular distribution of 3H-estradiol-17β has been studied by dry-mount autoradiography. Anterior pituitary cells and certain neurons show nuclear concentration and retention of the hormone similar to peripheral target tissues. This is interpreted, in conjunction with other data, as suggestive evidence of a genomic effect of estrogen in central target tissues, resulting in a stimulatory “feedback” (production of hormonal messengers) which may lead to a negative feedback effect on gonadal estrogen secretion by indirect action.
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