Abstract
In recent years, more and more researches have shown that Nectin-4 is a new type of tumor associated antigen. It is highly expressed in breast, ovarian, lung, urothelial, esophageal, liver, colorectal, gastric, gallbladder, bladder and pancreatic cancers, and promotes the development and progression of tumors. Nectin-4 is highly correlated with the prognosis of various tumors. The investigations and mechanism of nectin-4 in various tumor types is reviewed below.
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