Abstract
Introduction: One of the critical pathogenic agents in oral and dental bacteria is biofilm formation. Porphyromonas gingivalis (P. gingivalis) and Prevotella intermedia (P. intermedia) biofilms critically contribute to the unsuccessful treatment of oral and dental illnesses, and their permanent presence in dental canals harms the recovery process after treatment. Today, dentists are seeking superior and more beneficial choices with less toxicity as appropriate disinfectants for the mouth and teeth. Objective: The current research aimed to investigate the effects of Chlorhexidine (CHX) gluconate and matrica mouthwash on one-, three-, and five-day-old P. gingivalis and P. intermedia biofilms. Method: The biofilm formation capabilities of P.gingivalis and P.intermedia were assessed using the microtiter plate method. Subsequently, the Minimum Inhibitory Concentration (MIC) of CHX gluconate and matrica mouthwash at various concentrations against biofilm formation in P. gingivalis and P. intermedia was specified using the microdilution method. Results: The biofilm formation capabilities of P. gingivalis and P. intermedia were approved on a quantitative scale. Both CHX gluconate and matrica mouthwash were effective in eradicating biofilm formation in P. gingivalis and P. intermedia strains. Notably, according to the results, CHX mouthwash exhibited a greater efficacy in eradicating P. gingivalis biofilm. Furthermore, the matrica mouthwash capability to eradicate biofilms in P. gingivalis and P. intermedia was equivalent, with no significant difference observed. Conclusion: The CHX mouthwash is recommended as a novel approach for controlling biofilm infections stemming from oral and dental bacteria, including P. gingivalis and P. intermedia
Published Version
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