Abstract
Statistical learning and probabilistic inference techniques are used to infer the hand position of a subject from multi-electrode recordings of neural activity in motor cortex. First, an array of electrodes provides training data of neural firing conditioned on hand kinematics. We learn a non-parametric representation of this firing activity using a Bayesian model and rigorously compare it with previous models using cross-validation. Second, we infer a posterior probability distribution over hand motion conditioned on a sequence of neural test data using Bayesian inference. The learned firing models of multiple cells are used to define a non-Gaussian likelihood term which is combined with a prior probability for the kinematics. A particle filtering method is used to represent, update, and propagate the posterior distribution over time. The approach is compared with traditional linear filtering methods; the results suggest that it may be appropriate for neural prosthetic applications.
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