Proactive and reactive cognitive control for emotional conflict in individuals with high schizotypy: An ERP study

Abstract

ObjectiveThe present study aimed to examine how individuals with high schizotypy, a high risk group of schizophrenia patients, resolve emotional conflict in proactive and reactive control and the underlying neural mechanisms. MethodsThirty-two individuals with high schizotypy and 30 matched individuals with low schizotypy completed an emotional face–word Stroop task with electroencephalographic data recorded. The proportion of incongruent trials was manipulated in the task to induce proactive control (mostly incongruent trials context, MI context) or reactive control (mostly congruent trials context, MC context). Two event-related potential (ERP) components (N170 and N2) were examined, which represent face processing and cognitive control processes, respectively. ResultsIn the MC context, significantly decreased N2 and N170 amplitudes were found in high schizotypy individuals compared with low schizotypy individuals, suggesting abnormal neural activity of reactive control in high schizotypy individuals. No significant differences were found between the two groups in the MI context. ConclusionsThese results provide initial evidence for dissociation of neural activity of proactive and reactive control on emotional conflict in individuals with high schizotypy. SignificanceThe current findings provide important insight into the emotional conflict resolution in the schizophrenia spectrum.