Abstract

Venous air embolism as a complication of contrast media administration from power injection systems in CT is found to occur in 7%-55% of patients, impacting patient safety, diagnostic image quality, workflow efficiency, and patient and radiographer satisfaction. This study reviews the challenges associated with reactive air management approaches employed on contemporary systems, proposes a novel air management approach using proactive methods, and compares the impact of reactive and proactive approaches on injected air volumes under simulated clinical use. Injected air volumes from three power injection systems were measured under simulated clinical use via custom air trap fixture. Two of the systems employed reactive air management approaches, while a new system implemented the proposed proactive air management approach. The proactive system injected significantly less air (average of 0.005mL ± 0.006mL with a maximum of 0.017mL) when compared to two systems with reactive approaches (averages of 0.130mL ± 0.082mL and 0.106mL ± 0.094mL with maximums of 0.259mL and 0.311mL, respectively) (p < 0.05). CT images were taken of static and dynamic 0.1mL air bubbles inside of a vascular phantom, both of which were clearly visible. Additionally, the dynamic bubble was shown to introduce image artifacts similar to those observed clinically. Comparison of the injected air volumes show that a system with a proactive air management approach injected significantly less air compared to tested systems employing reactive approaches. The results indicate that the use of a proactive approach could significantly reduce the prevalence of observable, and potentially artifact-inducing, venous air embolism in contrast-enhanced CT procedures.

Highlights

  • O VER 200 million computed tomography (CT) procedures are performed annually throughout the world

  • For 15 of the 30 injections performed on CT motion, at least one visible bubble was observed in the patient line prior to injection, while the average injected air volume was 0.130 mL ± 0.082 mL with a maximum of 0.259 mL

  • In combination with the average measured air volume within the expected error distribution of the air trap fixture and the lack of observed air bubbles during simulated use, it can be reasonably interpreted that Centargo did not inject a detectable amount of air throughout the simulated clinical use. These findings suggest that the proactive air management strategy used for Centargo successfully eliminates the injection of air bubbles during simulated clinical use, while the reactive air management approaches used for the other tested systems allow detectable air volumes to be injected

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Summary

Introduction

O VER 200 million computed tomography (CT) procedures are performed annually throughout the world. Abnormalities such as atrial or ventricular septal defects or arteriovenous malformations may allow air that reaches the heart to transition into arterial circulation [4], [5]. In these cases air as small as 1 mL in volume may create blockages in vessels supplying the heart or brain, causing myocardial infarction or stroke [18], [19]. Examples of these malformations, such as a patent foramen ovale, are believed to be present in 25% to 35% of the population [20]

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