PRO96 BURDEN OF HOSPITALIZATIONS AND SERIOUS INFECTIONS IN ANTINEUTROPHIL CYTOPLASMIC ANTIBODY (ANCA)-ASSOCIATED VASCULITIS: AN ANALYSIS OF US NATIONAL IN-PATIENT SAMPLE DATABASE

Abstract

The objective of this study was to examine burden of hospital stay and rate of serious infections in patients with ANCA Vasculitis. The 2016 National Inpatient Sample (NIS) data set was analyzed to estimate the burden of hospital admissions in patients with ANCA Vasculitis and two subtypes, Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA). Patients ≥ 18 years old and with an ICD-10 diagnosis code M31.3, M31.31 or M31.7 were included (M30.1 was excluded). The rate of serious infections was estimated based on co-existing diagnosis for 70 different types of infections that were previously reported. In 2016, there were an estimated 13,535 hospital admissions with a diagnosis of ANCA Vasculitis (16% with principal diagnosis). The mean age was 62.6 years (SD: 16.3) and 54% of the patients were female. The mean length of stay (LOS) for patients with a diagnosis of ANCA Vasculitis was 7.6 days (SD: 9.0). The mean LOS was 9.6 (SD: 8.9), 9.2 (SD: 8.9) and 11.3 (SD: 8.3) days in patients with principal diagnosis of ANCA Vasculitis, GPA and MPA, respectively. The mean hospital charges for patients with a diagnosis of ANCA Vasculitis were $88,726 (SD: $144,020). The mean charges were $114,249 (SD: $ 148,382), $107,529 (SD: $140,486) and $145,766 (SD: $178,683) in patients with principal diagnosis of ANCA Vasculitis, GPA and MPA, respectively. The rates of serious infections were 37% in patients with any diagnosis of ANCA Vasculitis, and 27%, 27% and 30%, in patients with principal diagnosis of ANCA Vasculitis, GPA and MPA, respectively. Analysis of NIS database shows that patients with ANCA Vasculitis pose significant burden of hospitalizations and suffer from high rate of serious infections and mortality. There is an urgent need for new treatment options to improve outcomes for patients with ANCA Vasculitis.