Prioritization of Veterinary Medicines in China's Environment

Abstract

ABSTRACTLarge amounts of veterinary medicines are widely used as therapeutic drugs and feed additives (growth promoters) in China, the environmental presence of which possibly poses challenges to the environment and human health. Therefore, it is important to list the veterinary medicines that are considered to be of relatively high priority in China for environmental management. In this study, a three-stage prioritization scheme was applied to veterinary medicines in China. In Stage I, exposure assessment was conducted based on usage amounts and the possibility of entering the environment. In Stage II, the ecotoxicity and human health effects of compounds having a high potential to enter the environment were assessed. In Stage III, considering both the results of Stages I and II, veterinary medicines were assigned into four priority classifications. Using the approach, 38 compounds were assigned to “H,” 7 compounds to “M,” 2 compounds to “L,” and 22 compounds to “VL.” Among the top-ranked compounds, antibiotics, endoparasiticides, and aquacultural medicines accounted for 57.9%, 28.9%, and 10.5%, respectively. Insecticides used widely in China's aquaculture need to be taken into account due to their high priority rank. This is the first study on the prioritization of veterinary pharmaceuticals in China.