Abstract
Extractive electrospray ionization mass spectrometry (EESI-MS), an ambient ionization technique for direct analysis of complex samples without sample pretreatment, is undergoing rapid development, and has been wildly used in the analysis of liquids, aerosols, solid surfaces and viscous liquids. In this paper, the mechanism of EESI is introduced, the specific implementations and characteristics of EESI-MS in the analysis of real samples are described, and the new applications of EESI-MS are discussed. Moreover, the usability of EESI-MS in the field of food and drug safety; public security; chemical reaction mechanisms; metabolomics; protein analysis; clinical diagnostic and environmental monitoring are exemplified using cases demonstrated in the literature.
Published Version
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