Abstract
1. 1. Two fragments were isolated after cyanogen bromide cleavage of the aminoethylated β chain from the major hemoglobin of a New World monkey ( Cebus albifrons). Each fragment was digested with trypsin and the resulting peptides were isolated. The peptides were placed in sequence by homology with the corresponding peptides from the human β chain. The locations of residues that differ from those in the human β chain were deduced from analyses of the thermolysin peptides produced by subfragmentation of selected tryptic peptides. The β chain of C. albifrons differs from that of man at a minimum of seven positions; in addition, two residues (threonine and alanine) were found at position 13. 2. 2. Comparison with β chains from other New World monkeys, Old World monkeys and apes indicates that the ceboid β chains comprise a related group of polypeptide chains which are more similar to those of cercopithecoids than they are to those of hominoids.
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