Abstract
Sarcomatoid (spindle cell) carcinoma (SCPP) is a rare neoplasm that shows biphasic proliferation of a conventional squamous cell carcinoma component and malignant pleomorphic spindle cells with sarcomatous appearance. The development of SCPP in the floor of the mouth is rare. A 55-year-old male patient, smoker, presented a pedunculated irregular hard lesion located on the floor of the mouth and posterior left mandibular alveolar ridge. The lesion had been present for 2 months and was associated with light pain. Incisional biopsy and histologic analysis showed a malignant undifferentiated neoplasm that presented sheets of spindle cells intermixed with epithelioid and multinucleated giant cells that exhibited pleomorphism and hyperchromatism, in addition to typical and atypical mitosis. Immunohistochemical panel was positive for 34βE12, p63, vimentin, CKAE1/AE3 and Ki67 (70%), compatible with the diagnosis of SCPP. The patient was submitted to tumor resection and is currently under the supervision of the medical oncology team.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
