Abstract
Primary squamous cell carcinoma of breast is a rare disease. Incidence for primary SCC breast is 0.04-0.1 % of all malignancies of breast. A pure form of primary SCC breast is also described and its incidence is still less. Biologically it behaves differently and usually doesn’t metastasize to lymph nodes, though distant metastasis is more common. They occur usually in elderly women. Mean age of presentation is 54 years. We report the youngest patient so far - a 27 years old woman diagnosed initially as having fibrocystic disease and later as primary pure SCC breast. She did not have any other focus of malignancy in the body and is doing well 3-1/2 years post surgery and radiotherapy. DOI: http://dx.doi.org/10.3126/jpn.v4i7.10322 Journal of Pathology of Nepal (2014) Vol. 4, 600-602
Highlights
Squamous cell carcinoma [SCC] in breast may originate either from epidermis, nipple or from malignant transformation of a deep-seated epidermal cyst or metaplasia in a duct or medullary carcinoma or in a phylloides tumor.[1]
Types of primary SCC of breast as described by Azzopardi are:[5] a) Adenocarcinomashowingvaryingdegreesofsquamous differentiation, b) Metaplastic carcinoma with squamous cells and extensive spindle cell component mimicking fibro or carcinosarcoma, c) SCC arising in phylloides tumor and, d) Pure SCC
Origin of SCC in breast is believed to be an extreme form of squamous metaplasia developing in an adenocarcinoma.[1]
Summary
Squamous cell carcinoma [SCC] in breast may originate either from epidermis, nipple or from malignant transformation of a deep-seated epidermal cyst or metaplasia in a duct or medullary carcinoma or in a phylloides tumor.[1]. Correspondence: Dr Prakash Raje, MD Departments of Surgical Pathology and Cytology and Oncosurgery Bombay Hospital, Indore, India
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