Primary squamous cell carcinoma of breast: A Rare Case Report

Dr Rekha M Haravi,Dr Sabu N Satihal,Dr Bhumika J Bhandari,Dr Shreekant K Kittur

doi:10.17511/jopm.2017.i02.07

Abstract

Primary squamous cell carcinoma (SCC) of breast is a pure epithelial type of metaplastic carcinoma accounting for less than 0.1% of all breast cancers. A 70 year female presented with left breast lump of 4 months duration. Toilet mastectomy was done. Histopathology proved it to be primary SCC (large cell keratinizing) of breast. On immunohistochemistry, tumor cells were positive for pancytokeratin and epidermal growth factor receptor and negative for estrogen, progesterone receptors and HER-2/neu (triple negative). On follow up, after 1 month, patient presented with recurrence and metastasis to ipsilateral axillary lymph nodes. This case is presented for its rarity.

Highlights

Metaplastic carcinoma of breast accounts for less than 1% of all invasive mammary carcinomas [1]
We report a case of this rare breast malignancy in an elderly female with metastasis to ipsilateral axillary lymph nodes
There was no component of invasive ductal carcinoma or other types of metaplastic carcinomas

Summary

Introduction

Metaplastic carcinoma of breast accounts for less than 1% of all invasive mammary carcinomas [1]. Primary squamous cell carcinoma (SCC) of breast is a pure epithelial type of metaplastic carcinoma, accounting for less than 0.1% of all breast cancers [1,2]. We report a case of this rare breast malignancy in an elderly female with metastasis to ipsilateral axillary lymph nodes. A 70 year old woman presented with lump in left breast of 4 months duration with an overlying ulcer of 15 days duration.

Results

Conclusion