Abstract
Primary nephrotic syndrome(PNS) in children is a series of physiological and pathological changes caused by unknown reasons, in which increased glomerular filtration membrane permeability results in a large amount of proteinuria.It is considered to be related with immune system disorders.Programmed death 1(PD-1) is a member of the CD28/CTLA-4 family.The binding of PD-1 and its ligand(programmed death ligand 1, PD-L1) can activate PD-1/PD-L1 signaling pathway, which inhibits T cell activation, proliferation, differentiation and cytokine secretion, and negatively regulate immune responses and improve immune tolerance.This review briefly introduces the latest research progress of PNS in children and PD-1/PD-L1 signaling pathway. Key words: Children; Primary nephrotic syndrome; Programmed death 1; Programmed cleath ligand 1
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
