Primary Malignant Melanoma of the Female Urethra, A Rare Histologic Pathology Subtype and Poor Prognosis: Case Report

Abstract

Introduction: Primary malignant melanoma of the genitourinary tract is extremely rare. The recommendations for management of this cancer still undefined due to paucity of literature. We report a case of primary malignant urethral melanoma developed in an elderly female patient. Presentation of case: 72 years old Thai female presented with palpable urethral mass with contact bleeding. On physical examination, there were no suspicious lesions on her skin. On external genital examination, a lesion at urethral meatus was observed and biopsied by rural doctor. The pathological diagnosis was malignant melanoma of urethra. Discussion: Despite major surgery, radiotherapy or immunotherapy malignant melanoma usually has a poor prognosis. We performed distal urethrectomy and followed up her clinical closely but unfortunately tumor recurrence in 15 months of the follow up. Conclusion: Primary malignant melanoma of female urethra is an extremely rare and poor prognosis. The histological and immunohistochemical findings can be helpful in making an accurate diagnosis.