Primary malignant melanoma of female urethra: a case report and review of literature

Abstract

We report an extremely rare case report of primary malignant melanoma of female urethra. A 65 years old diabetic elderly postmenopausal female presented with a history of intermittent blood spots on undergarments for few days. Genital examination revealed a single, tan colored, soft chestnut size and polypoidal non ulcerated mass lesion protruding through the urethral meatus. Mass biopsy revealed poorly differentiated epithelial malignancy and immuno-histological analysis revealed positive with HMB 45 and protein S-100 suggestive of melanoma. Metastatic work up for the malignancy was negative. Complete urethrectomy with Mitrofanoff procedure with inguinal lymph node dissection was performed. Pathological diagnosis was malignant melanoma of urethra. We discuss the clinicopathological features and treatment option possible in this scenario.