Abstract
PurposeTo investigate the clinical characteristics and prognosis of primary malignant melanoma of the uterine cervix.ResultsThe median age of the patients was 61.2 years (range, 42-78 years). The median overall survival of the patients at stage I, II and III were 39.2 months, 47.8 months and 9.0 months (P=0.574) and the 2-year overall survival for each stage were 80.0%, 50.0% and 0.0% respectively. Twelve (85.7%) patients developed recurrence and eleven patients (78.6%) died. Ten patients received surgery and four patients were treated with chemotherapy and/or radiotherapy. Immunotherapy was administrated to two patients after surgery. The mean survival time of patients with surgery and without surgery were 47.9 vs.7.75 months (P=0.047). Patients received radical hysterectomy had longer survival than patients underwent total hysterectomy (66.8 months vs 19.5 months, P=0.016).MethodsClinical data from 14 patients with primary malignant melanoma of the cervix between January 1981 and December 2014 were reviewed.ConclusionsPatients with primary malignant melanoma of the cervix have a poor prognosis. Radical hysterectomy and pelvic lymphnode dissection may offer better prognosis for stage I and II patients.
Highlights
RESULTSMalignant melanoma (MM) is a rare malignant neoplasm of the skin and mucous membranes and accounts for about 1% of all cancers [1]
The mucosal malignant melanomas account for 0.03% of all cancers and occur in a variety of sites including the oral cavity, esophagus, anus, conjunctiva and gynecologic tract [2]. 5% female MM occur on the vulva, with rare cases detected in the ovary, uterus and cervix [3]
Primary malignant melanomas of cervix is an extremely rare disease which origin from the cervical melanocytic cells [9]
Summary
Malignant melanoma (MM) is a rare malignant neoplasm of the skin and mucous membranes and accounts for about 1% of all cancers [1]. The mucosal malignant melanomas account for 0.03% of all cancers and occur in a variety of sites including the oral cavity, esophagus, anus, conjunctiva and gynecologic tract [2]. 5% female MM occur on the vulva, with rare cases detected in the ovary, uterus and cervix [3]. Current treatment for mucosal melanoma is primarily based on experience from cutaneous mela-noma. To our knowledge a maximal cohort of 83 patients with primary MM of cervix were reported, and exhibited poor long term survival [8]. We reported 14 cases of primary MM of cervix and reviewed the literature. Our aim was to explore the best treatment strategy for this rare disease
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