Abstract
Cold autoimmune hemolytic anaemia (AIHA) has several causes, including Primary Cold Agglutinin (CAD). The cold AIHA in CAD is due to autoantibody anti-I. Most antibodies in cold AIHA are IgM subtype that optimally binds to red blood cells (RBCs) at 0°C–4°C. The presentation of the primary CAD is variable. Some patients presented with severe hemolytic anaemia and some incidentally had discrepancies in the laboratory results due to the cold agglutinin interferences. Here, we present a case of CAD secondary to clonal B Lymphoproliferative Disease (LPD). The patient presented with fever and had melaena. Upon blood taking for the investigations, the blood was easily clotted and his blood group showed discrepancy results forward and reverse.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
