Abstract
Preventive effect of olanzapine on trimethyltin neurotoxicity in mice: Evaluation of hippocampal neuronal loss, microglial activation, and cognitive dysfunction
Highlights
Hippocampal neuronal loss is a well-established pathology that causes cognitive dysfunction
The present study demonstrated for the first time that olanzapine prevents TMT from causing cognitive dysfunction, neurodegeneration, and microglial activation
Scale bar = 100 μm we found that microglial activation is, at least partly, involved in TMTinduced neurodegeneration
Summary
Hippocampal neuronal loss is a well-established pathology that causes cognitive dysfunction. Cognitive dysfunction due to progressive neurodegeneration occurs in a wide range of neurodegenerative disorders, including Alzheimer’s disease, cerebral ischemic insults, and Parkinson’s disease [1,2]. After TMTinduced neurodegeneration in the dentate gyrus, neurogenesis becomes markedly enhanced [7]. These features of TMT have become useful in the research on hippocampal neurodegeneration and neuroregeneration [8]. TMT induces abnormal behaviors, including cognitive dysfunction and depressive-like behaviors [7,9]. Previous studies have shown that TMT-treated mice are useful for analyzing psychiatric changes involved in neurodegeneration or neuroregeneration in the hippocampal dentate gyrus
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