Preventive effect of low-dose sufentanil combined with parecoxib sodium for hyperalgesia of remifentanil anesthesia after postoperative

Abstract

Objective To explore preventive effect of low-dose sufentanil combined with parecoxib sodium for hyperalgesia of remifentanil anesthesia after postoperative. Methods A total of 120 patients undergoing elective abdominal surgery under general anesthesia was randomly divided into three groups that were given intraoperative remifentanil infusion. At the 30 minutes before surgery, group A were given intravenous sufentanil 0.1 μg/kg combined with 40 mg parecoxib sodium, group B were given intravenous sufentanil 0.2 μg/kg combined with 40 mg parecoxib sodium, and group C were given normal saline 5 ml. Postoperative recovery time, extubation time, postoperative 1, 2, 6, 12, and 24 h visual analog scale (Visual Analogue Scale/Score, VAS) score, and after 24 h additional analgesia number of cases and the restless occurrence of three groups were compared. Results Awakening time and extubation time of group B was significantly longer than groups A and C [(10.9±1.3)min vs (8.6±0.6)min, (8.2±0.7)min; (14.0±2.1)min vs (10.7±2.2)min, ( 10.8±1.2)min, all P 0.05). Conclusions Low dose sufentanil together with parecoxib sodium can inhibit after-remifentanil-induced hyperalgesia, and will not appear awakening time and extubation time delays and safe. Key words: Sufentanil/AD; Cyclooxygenase 2 inhibitors/AD; Fentanyl/TU; Anesthesia; Hyperalgesia/PC