Abstract
The aim of this study was to investigate the effect of Lactobacillus plantarum HFY09 on gastric injury induced by HCl/ethanol in Kunming mice. The results showed that HFY09-H inhibited any increases in gastric juice volume, maintained the normal pH value of gastric acid, and reduced the damage caused to the gastric mucosa and gastric wall, the inhibition rate on the injury area reaches 63.70%. Compared with the negative control group, HFY09 increased the levels of serum somatostatin (SS) and vasoactive intestinal peptide (VIP), and also decreased the levels of substance P (SP), endothelin-1 (ET-1), interleukin-6 (IL-6), interleukin-12 (IL-12), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ). In addition, real time fluorescent quantitative PCR (Q-PCR) also confirmed that high-dose HFY09 (109 CFU/kg/day) upregulated the mRNA expression of copper/zinc superoxide dismutase (Cu/Zn-SOD), manganese superoxide dismutase (Mn-SOD), catalase (CAT), endothelial nitric oxide synthase (eNOS), and neuronal nitric oxide synthase (nNOS), and downregulated the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). At the same time, the results of the HFY09 treatment group were similar to those of the ranitidine treatment group. These results indicate that HFY09 can prevent gastric injury induced by HCl/ethanol in vivo. Therefore, HFY09 may play a potential role in the treatment of gastric diseases.
Highlights
Gastric injury is an infectious or chemical attack factor that breaks down the mucosal defense system, which will cause epithelial damage or ulcers in the stomach [1, 2]
On the first 14 days, the normal group and the negative control group were provided with free diet and drinking water, the ranitidine group was given ranitidine solution, the Lactobacillus plantarum HFY09 group was given low-and high-dose bacterial suspension, and Lactobacillus delbrueckii subspecies Bulgaria (LB) suspension was administered to the LB group
HFY09 can reduce the effect of gastric injury on gastric mucosa
Summary
Gastric injury is an infectious or chemical attack factor that breaks down the mucosal defense system, which will cause epithelial damage or ulcers in the stomach [1, 2]. Current research shows that bacteria, drugs, smoking, and alcohol consumption can cause gastric mucosal damage. Alcohol is the main component of alcohol. It is fat soluble and can produce acetaldehyde, which has a strong carcinogenic effect that begins from the time it Probiotics and some new biological drugs have been widely studied as new therapies to treat stomach-related diseases. There is growing evidence that probiotics are beneficial to host health [7]. Numerous studies have confirmed that yeast and lactobacillus are the main resident microorganisms in the stomach that are beneficial to the human body.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
