Abstract
Anji white tea (Camellia sinensis) is a traditional Chinese tea beverage, which is classified as green tea and contains an abundant amount of flavonoids. In this study, the preventive effect of Anji white tea flavonoids (AJWTFs) on ethanol/hydrochloric acid-induced gastric injury in mice was evaluated. The serum and gastric tissues of mice were analyzed using a biochemical kit and by quantitative polymerase chain reaction (qPCR). Observation of the appearance of the stomach indicated that AJWTFs could effectively reduce the area of gastric injury caused by ethanol/hydrochloric acid, and the inhibition rate of AJWTF on gastric injury increased with an increase in AJWTF concentration. The Anji white tea flavonoids could also reduce the volume and pH of gastric juice in mice with gastric injury. Biochemical results showed that AJWTFs could increase the superoxide dismutase (SOD) and glutathione (GSH) activities, as well as decrease the malondialdehyde (MDA) level, in the serum and liver of mice with gastric injury. Pathological observation confirmed that AJWTFs could inhibit the tissue damage caused by ethanol/hydrochloric acid in the stomach of mice. Further qPCR experiments also showed that AJWTFs could inhibit the decreases in neuronal nitric oxide synthase (nNOS), endothelial nitric oxide synthase (eNOS), copper/zinc superoxide dismutase (Cu/Zn–SOD), manganese superoxide dismutase (Mn–SOD), catalase (CAT), and the increase in inducible nitric oxide synthase (iNOS) expression in the gastric tissue of mice caused by gastric injury. As observed, AJWTFs exerted a good preventive effect on alcohol-induced gastric injury in mice induced by ethanol/hydrochloric acid, and the effect is close to that of ranitidine. Anji white tea flavonoids present good antioxidant effect, which allows them to effectively prevent alcoholic gastric injury and be used as biologically active substances with a broad range of applications.
Highlights
Alcoholic gastric injury is a gastric mucosal injury caused by excessive drinking, which often clinically manifests as gastritis
Anji white tea flavonoids could effectively reduce the increase in volume and decrease in pH of gastric juice as a result of gastric injury
The results indicated that Anji white tea flavonoids (AJWTFs) could reduce the free radical damage caused by ethanol and lipid peroxidation protecting the balance of antioxidant in vivo to inhibit alcohol-induced gastric injury
Summary
Alcoholic gastric injury is a gastric mucosal injury caused by excessive drinking, which often clinically manifests as gastritis. Ethanol directly damages the epithelial cells in the gastric mucosa, destroying the barrier of the gastric mucosa. Hydrophobic alkyl groups and hydrophilic hydroxyl groups of ethanol molecules can directly destroy the defense system of the gastric mucosa, rendering the gastric mucosa vulnerable to various digestive enzymes, bile, and gastric acid. This susceptibility leads to H+ antidiffusion, thereby aggravating the damage to the gastric mucosa. Increased ethanol concentration exerts a strong stimulating effect on the gastric mucosa and can cause necrosis of mucosal epithelial cells [3]. In addition to drug treatment, the preventive effect and application of bioactive substances on alcoholic gastric injury has research interest
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