Abstract
Liupao tea is a traditional Chinese tea drink. The preventive effect of crude polyphenols in Liupao tea on HCl/ethanol-induced gastric injury was investigated in this study. After a model of gastric injury in mice was established, mouse serum and tissues were analyzed by biochemical and molecular biological methods. The results showed that Liupao tea polyphenols (LTPs) could effectively reduce the area of gastric mucosal lesions, decrease the volume of gastric juice, and increase the pH of gastric juice in mice with gastric injury. Observations of the pathology revealed that LTPs could alleviate cell necrosis and gastric mucosal injury in mice with gastric injury. The SOD activity and GSH level were decreased in mice after gastric injury, while the level of MDA was increased. LTPs could inhibit the changes caused by gastric injury and make the SOD activity, GSH, and MDA levels close to the normal levels. In addition, LTPs could upregulate the mRNA expression of Cu/Zn-SOD, Mn-SOD, CAT, nNOS, and eNOS and downregulate the expression of iNOS in the gastric tissue of mice with gastric injury. Therefore, LTPs can effectively prevent HCl/ethanol-induced gastric injury. HPLC analysis showed that LTP contains six bioactive substances of gallic acid, catechin, caffeine, epicatechin, epigallocatechin gallate, and epicatechin gallate, so the effect of LTP might mainly come from these six components. The effect of a high concentration of LTP is similar to that of ranitidine. LTPs represent a kind of active substance with a protective effect on gastric tissue.
Highlights
Liupao tea is black tea named after the town where it was discovered: Liubao Township, Cangwu County, Wuzhou City, Guangxi Province
E mice research shows that Liupao tea contains various essential amino acids, vitamins, and trace elements and more lipid-decomposing enzymes than other types of tea. erefore, long-term drinking of Liupao tea has a strong effect on lipid metabolism in processes such as decomposing fat and reducing fat compounds, cholesterol, and triglycerides, and it helps with weight loss and contributes to fitness [2]
NOS exists in normal gastric tissue, and NOS will change significantly after gastric tissue injury. eNOS, nNOS, and iNOS will change [9]. erefore, this study chose these sensitive indicators for research
Summary
Liupao tea is black tea named after the town where it was discovered: Liubao Township, Cangwu County, Wuzhou City, Guangxi Province. E results showed that the LTPs could protect gastric tissue and avoid the damage caused by ethanol, and the effect of a high dose was better than that of a low dose.
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