Preventive effect of Cranberry gel on dentin submitted to erosion

Abstract

Objectives: Considering that Cranberry’s components might inhibit dentin metalloproteinases exposed to erosive agents, the aim of this study was to evaluate in situ effect of a Cranberry gel application on dentin before an erosive challenge.
 Methods: This crossover double-blinded study was performed in 2 phases of 5 days each, with 10 healthy volunteers who wore 2 palatal devices (1 for each phase) with 4 dentin specimens (2 specimens for each group). The groups under study were; First Phase: G1 - Erosive challenge (Coca-cola®) over dentin without any previous treatment (1st negative control group); G2 - Erosive challenge over dentin previously treated with Cranberry gel (test group); and Second Phase: G3 - Erosive challenge over dentin previously treated with a gel without any active principle (2ndnegative control group); G4 - Erosive challenge over dentin previously treated with 0.12% Chlorhexidine gel (positive control group). Each device was immersed into the acid beverage, 3 times daily for 5 minutes during 5 days. Profilometry (µm) was used to quantify the dentin wear. Data were analyzed by Repeated Measures Analysis of Variance followed by Fisher's test (p<0.05).
 Results: Data (G1: 4.98 ± 1.36a; G2: 3.29 ± 1.16b; G3: 4.38 ± 1.19a; G4: 3.32 ± 1.55b) showed no statistical difference between G1 and G3. There was also no difference between G2 and G4. However, G2 and G4 presented lower wear when compared to G1 and G3, and this difference was statistically significant.
 Conclusion: The results of this study suggest a significant efficacy of Cranberry gel in preventing wear of dentin subjected to dental erosion.
 
 Financial Support: FAPESP (Process 2012/16295-7) and MaRS IPoP Fund
 
 Keywords: Collagen, Dentin, Erosion, Preventive dentistry and Wear