Abstract
The hepatoprotective effect of ternatin, a tetramethoxyflavone from Egletes viscosa L. was investigated in mice against acetaminophen-induced hepatic damage and lethality. Hepatotoxicity was assessed by quantifying serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactic dehydrogenase (LD) and malondialdehyde (MDA) concentration in liver homogenates as well as by histopathological examination of liver tissue. Acetaminophen (300 mg/kg) produced liver damage in mice as manifested by a 29-, 23- and 7-fold rise in serum levels of ALT, AST and LD, respectively, compared with controls. Ternatin (25 and 50 mg/kg) was able to prevent significantly (p < 0.05) acetaminophen-induced acute increase in serum enzymes. In addition, the severity of histological alterations induced by acetaminophen as evidenced by centrilobular necrosis and cellular infiltration were greatly diminished in animals that received ternatin. The data suggest a hepatoprotective activity of ternatin in mice against toxicity induced by acetaminophen. Copyright © 1998 John Wiley & Sons, Ltd.
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