Preventing Antibiotic Resistance in the Wild: A New End Point for Environmental Risk Assessment

Abstract

Vol. 120, No. 8 News | Science SelectionsOpen AccessPreventing Antibiotic Resistance in the Wild: A New End Point for Environmental Risk Assessmentis accompanied bySelective Pressure of Antibiotic Pollution on Bacteria of Importance to Public Health Julia R. Barrett Julia R. Barrett Search for more papers by this author Published:1 August 2012https://doi.org/10.1289/ehp.120-a321aCited by:5View Article in:中文版AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InReddit Human and veterinary antibiotics enter the environment through wastewater effluent, agricultural use of manure and treated sewage for fertilizer, and leakage from waste storage facilities. This antibiotic pollution may exert selective pressure on bacteria to develop drug resistance, which is especially concerning if it develops in pathogenic bacteria. A new study weighs known bacterial antibiotic sensitivities against the backdrop of antibiotic concentrations measured in the environment and suggests that resistance in clinically relevant bacteria may not be kept in check by current risk assessment action levels [EHP 120(8):1100–1106; Tello et al.].Ciprofloxacin, erythromycin, and tetracycline were selected for the analysis from among the approximately 150 compounds for which minimum inhibitory concentrations (MICs) have been reported for different bacteria. An MIC is the amount of antibiotic needed to inhibit bacterial growth. Each of the three antibiotics affects a wide range of bacteria and represents a distinct class of antibiotics used in humans and animals. Concentrations of each antibiotic in various environmental compartments, or media, had been documented previously.Current guidelines for environmental risk assessment reflect the phase I action limits of the International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products. This program, which evaluates the safety of veterinary drugs, calls for environmental risk assessment of antibiotics whose concentrations exceed 1 ppb in aquatic compartments or 100 ppb in terrestrial compartments. These guidelines have been implemented in regulations in the United States, Europe, Japan, and Australia.www.jasonschneider.comThe researchers compared information on antibiotic levels in the environment with information on the MICs of clinically relevant bacteria to determine if current levels of antibiotic pollution might be high enough to promote the development of resistance. Within aquatic compartments, only a small fraction of the 27 bacterial genera included in the study were predicted to be affected by environmental concentrations of antibiotics, and results suggested that the phase I action level would protect against resistance. However, current levels of antibiotic pollution in terrestrial compartments—particularly in river sediments, liquid manure, and farmed soil—may be high enough to favor the evolution of bacterial resistance.The conclusions may be limited by long-term selective pressure and by the fact that MIC tests do not represent environmental conditions. Furthermore, the authors did not address bioavailability or the potential influences of antibiotic mixtures, metals, or disinfectants. Nevertheless, the potential for antibiotic pollution to increase antibiotic resistance in clinically relevant bacteria has important implications for public health and environmental health policy, and the authors demonstrate a possible framework for answering important outstanding questions about the environmental impact of antibiotics.FiguresReferencesRelatedDetailsCited by Zhang J, Ge H, Shi J, Tao H, Li B, Yu X, Zhang M, Xu Z, Xiao R and Li X (2022) A tiered probabilistic approach to assess antibiotic ecological and resistance development risks in the fresh surface waters of China, Ecotoxicology and Environmental Safety, 10.1016/j.ecoenv.2022.114018, 243, (114018), Online publication date: 1-Sep-2022. Silva V, Carvalho I, Igrejas G and Poeta P (2017) Soil Antibiotics and Transfer of Antibiotic Resistance Genes Affecting Wildlife Antibiotics and Antibiotics Resistance Genes in Soils, 10.1007/978-3-319-66260-2_16, (313-325), . Sousa M, Gonçalves A, Silva N, Serra R, Alcaide E, Zorrilla I, Torres C, Caniça M, Igrejas G and Poeta P (2014) Acquired antibiotic resistance among wild animals: the case of Iberian Lynx ( Lynx pardinus ) , Veterinary Quarterly, 10.1080/01652176.2014.949391, 34:2, (105-112), Online publication date: 3-Apr-2014. Marinho C, Santos T, Gonçalves A, Poeta P and Igrejas G (2016) A Decade-Long Commitment to Antimicrobial Resistance Surveillance in Portugal, Frontiers in Microbiology, 10.3389/fmicb.2016.01650, 07 Zhang Y and Li W (2018) Blending antibiotic resistance into environmental risk assessment of antibiotics: A case study in coastal waters of the Bohai Bay, China, Human and Ecological Risk Assessment: An International Journal, 10.1080/10807039.2018.1464381, (1-16) Related articlesSelective Pressure of Antibiotic Pollution on Bacteria of Importance to Public Health8 May 2012Environmental Health Perspectives Vol. 120, No. 8 August 2012Metrics About Article Metrics Publication History Originally published1 August 2012Published in print1 August 2012 Financial disclosuresPDF download License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. 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