Abstract
Antibacterial material nanocomposites are prepared to manufacture intravenous therapy (IV). These composites prepared by adding Magnesium oxide nano powder (MgO NPs) with a different percent (3, 6, and 9 wt %) to Silicone rubber (SR). The activity of this antibacterial material was inspected against S. aureus and E.coli microorganisms by using Agar Well Diffusion method.
 Results showed that the addition of MgO NPs to SiR causes the following enhancement the antibacterial activity against E.coli and S.aureus by 7.1% and 27.1% respectively, increasing tensile strength by 65.5%, increasing the hardness by11.25%, increasing the wear resistance by 84.5%, increasing surface bearing index (Sbi) by 80.5% , increasing in core fluid retention (Sci) by 8.5%, decreasing surface roughness (Sa) by 65%, decreasing core roughness depth (Sk) by 67% and enhancement the wettability by decreases contact angle to minimum value.
Highlights
In recent decades, nanocomposites have been taken into consideration because of their excellent properties and applications
Casting method is used to prepare the sheet of Silicone rubber (SR)/magnesium oxide (MgO) NPs by mixing 10g of SR mixed with (3, 6, and 9 wt %) Magnesium oxide nanopowders (MgO NPs) using bath sonication for 1h at 50°C, and the hardener is added in ratio (4:100) to the mixture and mixed for 5 min by a mechanical stirrer and pour in a suitable mold
Antibacterial activity of SR/MgO NPs composites was determined by measurement the diameter of inhibition zone after 24 h, In comparison with a control sample against Staphylococcus aureus (S. aureus) and Escherichia coli (E.coli) microorganisms, which are gram-positive and gram-negative respectively
Summary
Nanocomposites have been taken into consideration because of their excellent properties and applications. Contamination by microorganisms is the main factor in a variety of areas, such as medical devices, healthcare products, hospital, food storage, food packaging, and dental equipment etc. To overcome this problem different types of plastic material are sterilized and antisepsis by a different methods such as dry/wet heating or ionic radiation. Antibiotic-resistant bacteria, disease transmission, spread of infections and biocides formations are the main challenge of modern medical technology. To overcome these problems, antimicrobial polymers are used. MgO NPs are safe inorganic materials to human beings have antibacterial action against many microorganisms. MgO NPs has good antibacterial activity against many microorganisms such as E.coli and S.aureus and the inhibition zone increases with increase Mgo NPs concentration [11, 12]
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