Abstract
Abstract Funding Acknowledgements Type of funding sources: None. Main funding source(s): no. The purpose of the work to establish the prevalence of life-threatening arrhythmias and the risk of sudden death among people with a high and very high risk of cardiovascular diseases. Materials and methods During the period 2007-2013 years, we examined 4,214 patients, ages 35 to 85 years, who underwent Holter heart rhythm monitoring. Patients were divided into 4 groups. The 1st group: patients with coronary heart disease (stable angina), but without concomitant risk factors for cardiovascular diseases, such as smoking and obesity. The 2nd group - people who smoke 5 or more cigarettes per day for more than 2 years. The 3rd group - obese people without concomitant ischemic heart disease and arterial hypertension. The 4th group - people with obesity and hypertension. The control group included 149 practically healthy people. The groups were identical in age and sex. The highest prevalence of ventricular extrasystoles was recorded in group 2 (among smokers) and was 44,8% (p<0.01), and 9,02% of people from this group had class V ventricular extrasystoles according to V. Lown and M. Wolf classification, and the result was higher among people with stable angina, where this figure was 7,69%. The lowest prevalence of this arrhythmia was found among people with stable angina and was 30,34%. This can be explained by patients being more thoroughly supervised by doctors and medicine intake. Another reason was that groups 2-4 included people with only risk factors, and group 1 - people with the disease. Among obese people with and without hypertension, the prevalence of this arrhythmia was almost the same – 35,1% and 36,7%, respectively, and was not significantly different from the control group (33,6%). The next step was to determine the prevalence of polytopic (supraventricular + ventricular extrasystole) and ectopic foci among these individuals. And again, smokers had the highest prevalence of polytopic extrasystoles, which was 69,57%. Among people with stable angina, this figure was 55% (p<0.01). In people with obesity, which were included in the 3rd and 4th groups, polytopy was observed in less than half of the patients – 47,83% and 43,48%, respectively. Therefore, analyzing the data presented above, we can say that people who smoke tobacco have higher prevalence of both individual ventricular arrhythmia and ventricular and supraventricular extrasystoles than healthy individuals and people with obesity and hypertension. There is no significant difference in the prevalence of ventricular extrasystoles in individuals with only obesity or plus hypertension.
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