PREVALENCE OF TARGET ORGAN DAMAGE AND CARDIOVASCULAR RISK FACTORS IN PATIENTS OF THE IBERICAN STUDY

Abstract

Objective: The general aim of IBERICAN study is to know the prevalence and incidence of cardiovascular risk factors and cardiovascular and renal disease in Spain. The aim of this abstract is to know the prevalence of subclinical target organ damage (TOD) and cardiovascular risk in population of the IBERICAN Study. Design and method: The IBERICAN Study is a longitudinal, observational, and multicentric study with subjects between 18 to 85 years of age, recruited in Primary Care (PC) and who will be follow up at least 10 years. The final sample size is estimated in 8,066 patients. We show the baseline characteristics of the patients in the first visit (n = 8,066). To define the TOD, we consider the ESH 2013 Guide criteria: pressure pulse in aged > 60 mmHg, ankle/brachial index < 0.9, microalbuminuria: albumin/creatinine ratio (between 30 - 299 mg/g), glomerular filtration (CDK-EPI < 60 ml/min), left ventricular hypertrophy (electrocardiogram or ECHO). Results: 2,052 patients presented TOD (25.4%). The most frequent cardiovascular risk in patients with TOD are: hypertension in 73.7% vs 39.1% p< 0.001, dyslipidemia in 65.3% vs 45.1% p < 0.001, obesity in 43% vs 32, 5% p < 0.001, type 2 diabetes mellitus (T2DM) in 35.2% vs 15% p < 0.001, sedentary lifestyle 66.2% vs 27.8% p = 0.2 and smoking in 11.1% vs 19.9% p < 0.001. Of the patients with TOD and hypertension had good control 46.4% vs 66.6% p < 0.001, TOD and T2DM 74.4% vs 66.2% p = 0.8, TOD and dyslipidemia 22.2% vs 30 .2% p < 0.001. 57% (n = 1,170) of the patients with TOD met the criteria for Metabolic Syndrome and 23.3% (n = 477) met premorbid metabolic syndrome. Conclusions: All cardiovascular risk factors were more frequent in patients with TOD, except for smoking. The most frequent cardiovascular rissk was hypertension arterial and the worst controlled was dyslipidemia. TOD classifies patients as having high cardiovascular risk, so being able to detect it in patients with one or more cardiovascular risk factor is relevant for the optimal therapeutic approach in primary prevention.