PP.07.15] PREVALENCE AND CHARACTERISTICS OF THE PATIENTS WITH MICROALBUMINURIA IN THE IBERICAN STUDY

Abstract

Objective: The general aim of IBERICAN study is to know the prevalence and incidence of cardiovascular risk factors and cardiovascular and renal disease in Spain. The aim of this abstract is to know the prevalence of microalbuminuria and its relation with cardiovascular risk factors (CVRF), target organ damage (TOD) and cardiovascular-renal disease (CVD) in the IBERICAN Study Design and method: The IBERICAN Study is a longitudinal, observational, multicentric study with subjects between 18 to 85 years of age, recruited in Primary Care and who will be follow up at least 5 years. The final sample size is estimated in 7,000 patients. We show the baseline characteristics of the patients in the first visit (n = 3,042). We analyzed patients with microalbuminuria and we analyzed their association with the presence of CVRF, TOD (left ventricular hypertrophy (LVH), ankle/brachial index <0,9, glomerular filtration <60 ml/min) and with CVD. Microalbuminuria was defined: albumin/creatinine ratio between 30 and 299 mg/g, according to the Guide KDIGO-2012 Results: 3,042 subject including. 2,202 subject with albumin/creatinine ratio determined, microalbuminuria: 212 (9.6%, in men was higher than women: 13.3% vs 6.6%, p < 0.001), mean age 62.3 ± 14 years, 37.7% women. The prevalence of CVRF between microalbuminuria vs no microalbuminuria were: hypertension 72.2% vs 49,9%, p < 0.001; dyslipidemia 66% vs 51.6%, p < 0.001; diabetes 44.3% vs 19.1%, p < 0.001; obesity 41% vs 33.7%, p < 0.05; alcohol 19,3% vs 10,5%, p < 0,001; smoker 18% vs 16.4%, p = NS. TOD were more frequent with the microalbuminuria: LVH 13% vs 4.1%, p < 0.001; ankle/brachial index 26.8% vs 16.9%, p = NS; glomerular filtration < 60 ml/min 13% 24.4% vs 7.1%, p < 0.001. The prevalence of cardiovascular disease was higher in patients with microalbuminuria: 25.6% vs 15.4%, p < 0.001, ischemic heart disease 11.4% vs 7.9%, p = NS; stroke 8.1% vs 4.6%, p < 0.05; peripheral arterial disease 11.8% vs 4.4%, p = 0.001, and heart failure 7.1% vs 2.7%, p = 0.001. Cardiovascular risk high or very high was: 83.1% vs 59.4%, p < 0.001 Conclusions: Patients with microalbuminuria was more prevalent in men, with higher prevalence of cardiovascular risk factors, subclinical organ injury and established cardiovascular disease. The cardiovascular risk high or very high was more prevalent in patients with microalbumiuria.