Prevalence of sexual dysfunction in men with chronic prostatitis/chronic pelvic pain syndrome: a meta-analysis.

De-Ying Kang,Hong-Jun Li

doi:10.1007/s00345-015-1720-3

Abstract

PurposeThis study aims to estimate the prevalence of sexual dysfunction in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) by conducting a meta-analysis.MethodsRelevant publications were searched using PubMed, Embase, CBM, China National Knowledge Infrastructure, VIP and Wanfang databases up to August 2015. Studies that reported the prevalence of erectile dysfunction, premature ejaculation and total sexual dysfunction in men with CP/CPPS were included.ResultsA total of 24 studies involving 11,189 men were included. Overall prevalence of sexual dysfunction in men with CP/CPPS was 0.62 (95 % CI 0.48–0.75), while the prevalence of erectile dysfunction and premature ejaculation was 0.29 (95 % CI 0.24–0.33) and 0.40 (95 % CI 0.30–0.50), respectively. From 1999 to 2010, the prevalence of sexual dysfunction, erectile dysfunction and premature ejaculation was 0.65 (95 % CI 0.45–0.83), 0.27 (95 % CI 0.22–0.33) and 0.41 (95 % CI 0.27–0.55), respectively. From 2011 to 2014, the prevalence of sexual dysfunction, erectile dysfunction and premature ejaculation was 0.50 (95 % CI 0.22–0.75), 0.35 (95 % CI 0.29– 0.40) and 0.39 (95 % CI 0.37–0.41), respectively.ConclusionThe prevalence of sexual dysfunction in men with CP/CPPS was high, even though overall sexual dysfunction demonstrated a slightly decreasing trend. Furthermore, erectile dysfunction prevalence rate had an increasing trend in recent years. More prospective studies are needed to evaluate sexual dysfunction improvement with better management of CP/CPPS.Electronic supplementary materialThe online version of this article (doi:10.1007/s00345-015-1720-3) contains supplementary material, which is available to authorized users.

Highlights

Prostatitis is classified as acute bacterial prostatitis, chronic bacterial prostatitis, chronic prostatitis (CP)/chronic pelvic pain syndrome (CPPS, category III) and asymptomatic inflammatory prostatitis, according to the National Institutes of Health (NIH) prostatitis classification system [1]
Studies that met the following inclusion criteria were included: (1) any type of observational, cohort or crosssectional study, and case series; (2) original research written in English and Chinese; (3) studies that provide the prevalence of sexual dysfunction in men with chronic prostatitis/ chronic pelvic pain syndrome (CP/CPPS) or the total number and the number of sexual dysfunction participants; and (4) studies that at least reported the prevalence of overall sexual dysfunction, erectile dysfunction or premature ejaculation
Stratified analysis by geographical area revealed that the prevalence of erectile dysfunction and premature ejaculation appeared to be low in China than in Western nations

Summary

Introduction

Prostatitis is classified as acute bacterial prostatitis (category I), chronic bacterial prostatitis (category II), chronic prostatitis (CP)/chronic pelvic pain syndrome (CPPS, category III) and asymptomatic inflammatory prostatitis (category IV), according to the National Institutes of Health (NIH) prostatitis classification system [1]. CP/CPPS, a very common urologic problem, has trivial and complicated symptoms that severely impact the quality of life of patients. Given that monotherapies are usually less effective for alleviating symptoms [2], the UPOINT clinical phenotypic classification system, which has placed major concerns on diversified symptoms, has been established to addresses this puzzle. In this classification system, the phenotype of patients with CP/CPPS is classified into six clinical domains: urinary, psychosocial, organ-specific, infection, neurologic/systemic and tenderness of muscles [3]. The classification and specific treatment of men with CP/ CPPS using the UPOINT system have greatly improved the. The UPOINT classification does not consider sexual dysfunction, and the inclusion of a sexual dysfunction domain to the UPOINT system is continuously being debated [4]

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