Abstract
The Rhesus blood group system is one of the most polymorphic and highly immunogenic systems in humans. Because of its high and strong immunogenicity Rh D antigen testing is mandatory before issuing a compatible blood. There are five major antigens i.e. DCEce in the Rhesus (Rh) blood group system. On the other hand from the immunogenicity point of view Kell antigen is next to the Rh system. Both of them may cause severe hemolytic transfusion reaction and hemolytic disease of fetus and new born. Exposure of Rhesus negative individuals to Rhesus positive blood through transfusion or pregnancy is most likely to stimulate production of Rhesus antibodies. These antibodies may cause Hemolytic Disease of Fetus and Newborn (HDFN) and Delayed Hemolytic Transfusion Reaction (DHTR). Like Rhesus antibodies, Kell antibodies may also cause HDFN and DHTR. So far we know, there is not enough study regarding antigens C, c, E & e of Rh or K, k antigen of Kell blood group system regarding these antigens in the donors in Bangladesh, thereby exposing transfused patients to these antigens negative patients. To determine the phenotype prevalence of the Rh and Kell blood group systems in the blood donors in Bangladesh, a descriptive cross sectional study was done in the laboratory of Department of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University, during the period of 1st January 2020 to 31 December 2020. Rhesus Phenotype CCDee is highest (48.4%) & CCDEe & ccDEE both are lowest (0.4%). Most probable Rhesus Genotype CDe/CDe (R1R1) is highest (48.4%) and CDe/CDE (R1Rz) & cDE/cDE (R2R2) both are lowest (0.4%). Kell Genotype kk is highest (99.2%) and Kk is lowest (0.8%). BSMMU J 2021; 14(3): 38-42
Highlights
Cite this arƟcle: Khatun A, Shaheen SSI, Rahman A, Saha S, Basak SK
Blood donors coming to the Department of Transfusion Medicine, BSMMU fulfilling inclusion criteria were taken as sample by purposive convenient sampling technique
Most probable Rhesus Genotype CDe/CDe (R1R1) is highest (48.4%) and CDe/CDE (R1Rz) & cDE/cDE (R2R2) both are lowest (0.4%)
Summary
Cite this arƟcle: Khatun A, Shaheen SSI, Rahman A, Saha S, Basak SK. Copyright: The copyright of this arƟcle is retained by the author(s) [AtribuƟon CC-By 4.0]. A Journal of Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Karl Landsteiner and Wiener discovered Rhesus (Rh) antigen in 1940, one of the most polymorphic and immunogenic systems is Rhesus (Rh) system. As it is highly immunogenic, testing for the RhD along with the A, B antigens has been made mandatory in pre-transfusion testing. There are more than 52 antigens in the Rh blood group discovered at present, but the major ones are D,C,E, c and e. In the Kell blood group system, more than 24 antigens have been discovered, among them Kell (K) and k (Cellano) is the most important
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Bangabandhu Sheikh Mujib Medical University Journal
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
