Abstract
BackgroundPremature ovarian insufficiency (POI) considered as a concerning health issue for women of reproductive age. In this study we aim to estimate the prevalence of POI and assessing the influential factors.MethodsData was obtained from Tehran lipid and glucose study (TLGS). All eligible post-menarcheal female participants of the TLGS, ages 20–65, were recruited (n = 6521). Participants were followed for the event of menopause, and age at menopause was recorded. Kaplan Meier analysis was applied to estimate mean and median for age at menopause. Weibull accelerated failure time survival regression model (AFT), was applied to assess influential determinants of POI. Conditional probability approach was used to provide estimation for prevalence of POI.ResultsIn this population-based study, the prevalence of POI (menopause age < 40 years) and early menopause (menopause age < 45 years) were estimated 3.5% and 24.6%, respectively. AFT model showed that in comparison to normal weight women, time to menopause was decreased by − 0.09 year (95% CI − 0.27, − 0.01, p = 0.023) and − 0.03 year (95% CI − 0.05, − 0.02, p = 0.000) in underweight and overweight women, respectively. Moreover, time to natural menopause was increased by 0.12 year (95% CI 0.07 to 0.17, p = 0.000) in women used oral contraceptives for > 6 months.ConclusionAbout one quartile of Iranian women experienced menopause at an age less than 45, especially the non-normal weight ones; this high prevalence is a critical public health concerns that needs to be addressed by health policy makers.
Highlights
Premature ovarian insufficiency (POI) considered as a concerning health issue for women of reproduc‐ tive age
We provide an estimation for POI, using data collected in the Tehran Lipid and Glucose Study (TLGS) and explore the risk factors among the general population of Iranian women
The ageadjusted accelerated failure time (AFT) survival model revealed a significant positive association between oral contraceptive (OC) use (> 6 months) and at natural menopause (ANM) ((0.12); a negative association between body mass index (BMI) − 0.001 and ANM was observed (Table 3)
Summary
Premature ovarian insufficiency (POI) considered as a concerning health issue for women of reproduc‐ tive age. Rostami Dovom et al BMC Women’s Health (2021) 21:79 and calculated the prevalence of POI by dividing the number of observed POI in the study population to the total number of married participants [11]. In another approach, participants were restricted to menopausal women [9] and the percentage of women with age at menopause < 40 was reported as the prevalence of POI; this restriction highly influenced the results and may have led to an increased risk of bias in the reported prevalence. We provide an estimation for POI, using data collected in the Tehran Lipid and Glucose Study (TLGS) and explore the risk factors among the general population of Iranian women
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