Abstract
The 2017 American College of Cardiology and American Heart Association (ACC/AHA) blood pressure (BP) guidelines redefined hypertension using a BP threshold of 130/80 mm Hg or greater and applied a treatment target of less than 130/80 mm Hg. To evaluate the potential change in the diagnosis, treatment, and control of hypertension in a Canadian cohort of patients with hypertension attending primary care practices using the ACC/AHA guidelines. This cross-sectional study used primary care practices across Canada electronic medical record data from the Canadian Primary Care Sentinel Surveillance Network, extracted as of June 30, 2015. Adults with at least 1 primary care encounter in the previous 2 years (July 1, 2013, to June 30, 2015) were included in the study. Those with current hypertension were identified using a validated definition consisting of diagnoses, billing codes, and/or antihypertensive medication from within the primary care electronic medical record. Data analysis was conducted from December 2017 to July 2018. Proportion of individuals with a diagnosis of hypertension, prescribed antihypertensive medication, and meeting treatment BP targets. Of the 594 492 Canadian participants included in the study, 144 348 (24.2%) had hypertension (45.6% male; mean [SD] age, 65.5 [14.5] years). On applying the ACC/AHA guidelines, 252 279 individuals (42.4%) were considered hypertensive and half (51.0%; 95% CI, 50.8%-51.2%) were prescribed an antihypertensive medication. Individuals who were not previously considered to have hypertension but were reclassified as having elevated BP using the lower cutoff of 130/80 mm Hg or greater tended to be younger and were at lower cardiovascular risk. There was a shift toward more individuals requiring antihypertensive treatment, particularly in the lower-risk categories. The crude prevalence of hypertension increased from 13.3% to 32.0% in those aged 18 to 64 years, and of those aged 65 years and older, 16.6% more individuals were reclassified as having hypertension (from 55.2% to 71.8%). Only 12.3% of those who were considered at high risk were reclassified as hypertensive. Adoption of the ACC/AHA BP guidelines would result in a near doubling in the prevalence of hypertension in Canada. The changes would largely affect individuals who are younger and at low to moderate cardiovascular risk.
Highlights
The 2017 American College of Cardiology and American Heart Association (ACC/AHA) blood pressure (BP) guidelines introduced a number of striking changes to the diagnosis and management of hypertension.[1]
Adoption of the American College of Cardiology/American Heart Association (ACC/AHA) BP guidelines would result in a near doubling in the prevalence of hypertension in Canada
These recommendations were largely based on observational data reporting a linear association between BP and coronary heart disease, stroke, and death, even with BP levels as low as 120-129/80-89 mm Hg,[2,3,4,5,6] as well as the Systolic Blood Pressure Intervention Trial (SPRINT) which reported a reduction in major cardiovascular events with an intensive systolic BP target less than 120 mm Hg compared with less than 140 mm Hg.[7]
Summary
The 2017 American College of Cardiology and American Heart Association (ACC/AHA) blood pressure (BP) guidelines introduced a number of striking changes to the diagnosis and management of hypertension.[1]. Pharmacological treatment would be recommended for 4.2 million treatment-naive individuals and another 7.9 million people may require treatment intensification.[20]
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