Abstract
To find out the proportion of HPV sub types 16 & 18 in invasive cervical carcinoma. This is a prospective observational study performed on 100 women with invasive cervical cancer. RT PCR was performed on the DNA extracted from the punch biopsy using RNA primers specific for subtypes 16 and 18. The mean age of the population was 53.25 years. The mean age of coitus was 19.25 years. Around 70% of the patients belong to class 4 or above socioeconomic status. The most common presenting symptom was vaginal discharge seen in 40% of the cases. The most common stage was stage IIB (40%) followed by IIIB (22%). 52% of the population had Grade 3 disease. In our study, the proportion of HPV-positive cancer was 64%. 60% of the patients were positive for HPV 16 subtype, and 22% were positive for HPV 18 subtypes. 18% were positive for both HPV 16 and 18. All stage IV A and IV B patients had HPV positivity. Around two-third of the cervical cancer are attributed to high-risk HPV 16 and 18. Bivalent vaccine can reduce a significant proportion of cases in our country.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call