Prevalence of HIV, Hepatitis B and C Virus Co-infections among Iranian High-Risk Groups: A Systematic Review and Meta-Analysis.

Yousef Moradi,Farzin Sadeghi,Amir Almasi Hashiani,Kamyar Mansori,Behzad Gholamaliei,Erfan Ayubi, , ,Salman Khazaei,Shahab Rezaeian,Abolfazl Mohammadbeigi

doi:10.21315/mjms2019.26.3.3

Abstract

Co-infection with hepatitis B and C among HIV infected patients are prevalent among high-risk populations. This meta-analysis aimed to estimate the prevalence of HIV, HCV and HBV co-infections among high-risk populations in Iran.We systematically searched the national and international electronic databases until 2016. The primary outcome was the prevalence of HIV, HBV, HCV and HIV co-infections in different high-risk populations in Iran. All English and Persian studies conducted on Iranian high-risk groups were included in the study. The review was reported based on PRISMA guidelines and data were analysed at 95% confidence level using random effect models.Overall, 916 relevant papers were recognised and 14 articles were included in the meta-analysis. The pooled estimates of HBV/HCV, HCV/HIV, HBV/HIV and HBV/HCV/HIV were 1.3% (95%CI: 0.5–2.1), 16.3% (95%CI: 1.1–31.6), 0.5% (95%CI: 0–1.4) and 0.5% (95%CI: 0.2–0.8), respectively. Based on subgroup analysis, there was a higher proportion of all co-infections from the years 2010–2016 as compared to that of the years 2003–2009.Our results highlighted that HCV/HIV co-infection in Iranian high-risk groups including injection drug users (IDUs) and prisoners is common. In addition, the increasing trend of coinfections should be considered alarming for policymakers.

Highlights

The prevalence and burden of HIV infection varies widely among developed and developing countries [1]
This review was performed in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement issued in 2009 [10]
The results showed that the pooled prevalence of all co-infections in the second period (2010–2016) were higher compared to the first period

Summary

Introduction

The prevalence and burden of HIV infection varies widely among developed and developing countries [1]. Co-infection with hepatitis B and C among HIV infection patients are more prevalent [4] especially among high-risk groups such as prisoners and people who inject drugs (PWID) [5, 6]. These infections have been reported as one of the most important causes of liver-related morbidity and mortality worldwide [7, 8]

Methods

Results

Discussion

Conclusion