Abstract
Aim. To examine prevalence and characterization of HBV and HCV coinfection among HIV/AIDS patients. Methods. This cross-sectional, retrospective study analyzed 724 HIV/AIDS patients in the HIV clinic at the National Hospital of Tropical Diseases (NHTD), from 5/2005 to 4/2011. Results. The prevalence of HBV, HCV, and HIV coinfection was 50.3% (364/724), of which HbsAg, HCV, and both of HbsAg, and HCV positivity were 8.4%, 35.4%, and 6.5%, respectively. The cohort (364 patients) with HBV, HCV, and HIV coinfection live in the 30 provinces/cities in the North and Central area of Vietnam. We found statistically significant associations between heightened risk of coinfection with HIV and HCV in the age group 30–39 years (P < 0.001), male gender (P < 0.001), never married patients (P < 0.001), patients with a history of injection drug use (P < 0.001), and clinical stages 2–4 (P < 0.001). Coinfection with HBV/HIV was statistically significant associations between heightened risk of marital status (never married) (P < 0.001) and those who reported transmission through sexual intercourse. Conclusion. Coinfection with viral hepatitis is common in HIV patients; further study of the impact and evolution of coinfection is necessary to find effective treatment algorithms.
Highlights
Hepatitis B virus (HBV) and hepatitis C Virus (HCV) are among the primary causes of morbidity and mortality in HIV patients
We reviewed data on 724 HIV positive patients treated at the HIV outpatient clinic in National Hospital of Tropical Diseases (NHTD) during the study period
Coinfection with viral hepatitis is common in HIV patients
Summary
Hepatitis B virus (HBV) and hepatitis C Virus (HCV) are among the primary causes of morbidity and mortality in HIV patients. In Vietnam, previous studies have reported various prevalence values of HBV, HCV, and HIV coinfection These studies were evaluated in different provinces and in individuals with different risk factors [9, 10], even assessed on blood samples stored [11]. According to these reports, in Bac Ninh province the HIV, HBV, and HCV prevalence was 42.4%, 80.9%, and 74.1% in injection drug user [9]; in Hai Phong city the cumulative HBV incidence rate was 53.2% in drug users, 51.6% in female sex workers, 54.3% in seafarers, and 50.5% in pregnant women [10]
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