Prevalence of Helicobacter pylori in type 2 diabetic patients: a meta-analysis

Abstract

Objective To systematically assess the prevalence of Helicobacter pylori in patients with type 2 diabetes mellitus. Methods Medline (PubMed) and EMBASE data-bases were searched from January 1990 to May 2015. Studies that provided data on Helicobacter pylori infection rate in both type 2 diabetes and control groups were selected. The quality of these studies was assessed using the Newcastle-Ottawa Quality Assessment Scale by two researchers, respectively. Meta-analysis was performed using the random effects model. Odd ratios (OR) and 95% Confidence Interval (CI) were calculated by STATA 12.0. Results Thirteen studies were included, OR of Helicobacter pylori infection rate was 1.70 (95% CI: 1.30-2.22, P=0.013) in patients with type 2 diabetes compared with control group. In subgroup analysis, the prevalence of Helicobacter pylori was higher in patients in Asia compared with control group(OR = 1.81, 95% CI: 1.25-2.61, P=0.025). The prevalence of Helicobacter pylori was higher in diabetic patients in gastric mucosal biopsy group compared with control group(OR=1.65, 95% CI: 1.10-2.46, P=0.002). Conclusion Patients with type 2 diabetes mellitus may have a higher risk of Helicobacter pylori infection. Key words: Type 2 diabetes mellitus; Helicobacter pylori; Prevalence; Meta-analysis