Association between Helicobacter pylori infection and type 2 diabetes mellitus

Abstract

Objective To assess the association between H. pylori infection and type 2 diabetes mellitus (T2DM) . Methods We conducted cross-sectional analysis on 2 050 subjects who received health examination from January 2010 to June 2012 in Tongji Hospital of Wuhan by using data of demographic characteristics and blood biochemical metabolism index such as fasting blood-glucose, glucosylated hemoglobin, etc. By 14C-Urea Breath Test (14C-UBT) , the participants were divided into H. pylori infection group and H. pylori negative group to analyze the relationship between H.pylori infection and T2DM. Results The H. pylori infection group had significantly higher morbidity of T2DM than H. pylori negative group (15.14% vs 12.06%, χ2=4.08, P<0.05) . The subjects were divided into different groups by gender, age and BMI, the morbidity of T2DM was higher in H. pylori positive subjects than in H. pylori negative subjects in ≥ 45 year-old group (18.08% vs 13.57%, χ2=4.09, P<0.05) . Multivariable logistic regression was used for further analysis. After adjustment for age and gender, H. pylori infection was positively associated with T2DM morbidity (OR=1.349, 95%CI: 1.021-1.783) . The association was attenuated after additional adjustment for smoking, drinking, hypertension, coronary heart disease, dyslipidemia and BMI (OR=1.333, 95%CI: 1.010-1.776) . Furthermore, the association was disappeared after additional adjustment for white blood cell (WBC) level (OR=1.261, 95%CI: 0.943-1.678) . Conclusions The H. pylori infection group has significantly higher prevalence of T2DM than H. pylori negative group in middle-aged and elderly subjects. Key words: Helicobacter pylori; Type 2 diabetes mellitus; Fasting blood glucose; Glucosylated hemoglobin