Abstract
Helicobacter pylori prevalence is decreasing globally and prevalence of non H. pylori gastric ulcers is increasing. The following study was conducted to assess the prevalence of H. pylori in benign gastric ulcers in a sample of Sri Lankan patients. This was a cross-sectional study of 59 dyspeptic patients with benign gastric ulcers. Multiple endoscopic gastric biopsies were obtained and histology, immunohistochemistry and polymerase chain reaction were performed for H. pylori detection. An immunochromatography assay was performed to detect blood anti H. pylori antibodies. Four (6.8%) were positive for H. pylori. Therefore, it is likely that most benign gastric ulcers are of non-H. pylori aetiology.
Highlights
With the description of a curved rod shaped bacterium (Helicobacter pylori) in a benign gastric ulcer in 1980s there was much enthusiasm to investigate the role of H. pylori in the pathogenesis of gastro-duodenal diseases [1]
More recent studies have indicated that the association between H. pylori infection and peptic ulcer disease is not as strong as indicated in previous literature [3,4,5,6]
Proportion of non-steroidal antiinflammatory drugs (NSAIDs) related peptic ulceration and non-NSAID, non-H. pylori ulcers are increasing in Western as well as in some developed Asian countries [36]
Summary
With the description of a curved rod shaped bacterium (Helicobacter pylori) in a benign gastric ulcer in 1980s there was much enthusiasm to investigate the role of H. pylori in the pathogenesis of gastro-duodenal diseases [1]. Studies have indicated 70 to 90% prevalence of H. pylori infection in benign gastric ulcers and 90 to 100% in duodenal ulcers [2]. Proportion of non-steroidal antiinflammatory drugs (NSAIDs) related peptic ulceration and non-NSAID, non-H. pylori ulcers are increasing in Western as well as in some developed Asian countries [36]. These observations indicate that the role of H. pylori in the pathogenesis of peptic ulcer disease is decreasing
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