Abstract
The profile of HIV-associated cardiovascular disease has changed with the high coverage of antiretroviral treatment (ART). Data are lacking in Gabon. To compare the type and the frequency of cardiovascular manifestations in hospitalized HIV-infected patients (PLHIV) and seronegative ones. This was a retrospective analytical study performed by analyzing the files of patients hospitalized for a cardiovascular diseases and who benefited from an HIV serology in the cardiology department of the centre hospitalier universitaire de Libreville from January 2015 to December 2018. The files of 82 PLHIV and 150 HIV negative were analyzed. The mean CD4 count in PLHIV was 189 ± 170/mm 3 and 45.1% were on ART. PLHIV were more frequently less than 50 years old (70.6% vs. 43.3% of HIV negative; P < 0.01) and they were more frequently female (67.1% vs. 36.0% of HIV negative; P < 0.01). Pericarditis (25.6% vs. 11.3% in seronegatives; P = 0.01) mainly due to tuberculous (85.2%), myocarditis (14.6% vs. 4.0% in seronegatives; P = 0.03) and repolarization disorders (32.9% vs. 15.3% in HIV negative; P < 0.01) predominated in PLHIV. Atheromatous vascular diseases were more frequent in HIV negative patients (23.1%) compared to seropositive (6.1%) ( P < 0.01). The death of PLHIV was mainly due to pericarditis (71.4%) while HIV negative patients died more frequently for heart failure (46.7%). The cardiovascular manifestations linked to HIV immunosuppression are still frequent in Libreville.
Published Version
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