Prevalence of aspirin resistance in patients with type II diabetes: a descriptive-analytical study .

Abstract

Aspirin resistance is one of the most important factors for arterial thrombotic events in diabetic patients. This study aimed to evaluate aspirin resistance in diabetic patients. In this cross-sectional study, 180patients who received 80mg of aspirin daily for at least 10 days were studied, and their urinary 11-DH-TXB2 was measured. Those with 11-dehydro-thromboxane B2 above 1,500pg/mg creatinine were considered aspirin resistant. Data with significance level of 5% were analyzed in SPSS-16. The mean±SD of patient age was 60.22±9.59 years and 50% (n=90) were male. BMI was normal in 29.4% of the patients (n=53), the others were overweight or obese. Aspirin resistance was observed in 33 (18%) patients. The relationship between aspirin resistance and gender, age, and BMI was not significant (p>0.05). There is a high prevalence of aspirin resistance in diabetic patients and given that such patients are at risk of arterial thrombotic events, evaluation of aspirin resistance is suggested for those at a high risk of cardiovascular events or recurring events despite the use of aspirin. .